Effects of undenatured whey protein supplementation on CXCL12- and CCL21-mediated B and T cell chemotaxis in diabetic mice

Effects of undenatured whey protein supplementation on CXCL12- and CCL21-mediated B and T cell chemotaxis in diabetic mice

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Abstract Background Long and persistent uncontrolled diabetes tends to degenerate the immune system and leads to an increased incidence of infection.Whey proteins (WPs) enhance immunity during early life and have a protective role in some immune disorders.In this study, the effects of camel WP on the chemotaxis of B and T cells to CDA FWC624SS Wine Cooler - Stainless Steel CXCL12 and CCL21 in diabetic mice were investigated.Results Flow cytometric analysis of the surface expressions of CXCR4 (CXCL12 receptor) and CCR7 (CCL21 receptor) on B and T cells revealed that the surface expressions of CXCR4 and CCR7 were not significantly altered in diabetic and WP-supplemented diabetic mice compared with control mice.

Nevertheless, B and T lymphocytes from diabetic mice were found to be in a stunned state, Divertor Check Valve with a marked and significant (P Conclusion Our data revealed the benefits of WP supplementation in enhancing cytoskeletal rearrangement and chemotaxis in B and T cells, and subsequently improving the immune response in diabetic mice.